Outline - Cell Division

1.6.U1 Mitosis is division of the nucleus into two genetically identical daughter nuclei.

State the function of mitosis.
List processes which involve mitosis.
State the names of the four phases of mitosis.
Draw typical eukaryotic cells as they would appear during the four phases of mitosis.
Outline four events that occur during prophase.
Outline the process of metaphase.
Outline the process of anaphase.
Outline four events that occur during telophase.

1.6.U2 Chromosomes condense by supercoiling during mitosis.

Describe the structure of a replicated chromosome, include the centromere and sister chromatids.
Explain why chromosomes must condense during mitosis.

1.6.U3 Cytokinesis occurs after mitosis and is different in plants and animal cells.

Define cytokinesis.
State the difference between mitosis and cytokinesis.
Contrast cytokinesis in plant and animal cells.
Describe the formation of the cleavage furrow in animal cell cytokinesis.
Describe the formation of the middle lamella and cell wall in plant cell cytokinesis.

1.6.U4 Interphase is a very active phase of the cell cycle with many processes occurring in the nucleus and cytoplasm.

1.6.U5 Cyclins are involved in the control of the cell cycle.

Explain the role of cyclin and cyclin-CDK complexes in controlling the cell cycle.
State the role of cyclins D, B, A and E in the cell cycle.

1.6.U6 Mutagens, oncogenes and metastasis are involved in the development of primary and secondary tumors.

1.6.A1 The correlation between smoking and incidence of cancers.

Explain the use of correlations to determine the relationship between two variables (inclusive of positive and negative correlations).
Explain why the existence of a correlation does not necessitate a causal relationship between two variables.
Calculate a correlation coefficient using Pearson's R.
Determine if a correlation coefficient value is significant.
Define significant as related to the relationship between two variables.
Use epidemiological case study information to outline the relationships between smoking and cancer.

1.6.S1 Identification of phases of mitosis in cells viewed with a microscope or in a micrograph.

Determine the phase of mitosis of a cell viewed in a micrograph or with a microscope.

1.6.S2 Determination of a mitotic index from a micrograph

State the formula for calculation of a mitotic index.
Calculate the mitotic index of a tissue as seen in a micrograph.
Outline the use of mitotic index calculations in diagnosis and treatment of cancer.

1.6.NOS Serendipity and scientific discoveries- the discoveries of cyclins was accidental.